STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
نویسندگان
چکیده
منابع مشابه
p38 inhibition provides anti–DNA virus immunity by regulation of USP21 phosphorylation and STING activation
Stimulator of IFN genes (STING) is a central adaptor protein that mediates the innate immune responses to DNA virus infection. Although ubiquitination is essential for STING function, how the ubiquitination/deubiquitination system is regulated by virus infection to control STING activity remains unknown. In this study, we found that USP21 is an important deubiquitinating enzyme for STING and th...
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ژورنال
عنوان ژورنال: Cell
سال: 2019
ISSN: 0092-8674
DOI: 10.1016/j.cell.2019.05.036